TITRATION
Flexible, once-daily XCOPRI dosing is titrated at 2-week intervals1
XCOPRI CAN BE PRESCRIBED AS MONOTHERAPY OR ADJUNCTIVE THERAPY1
Once-daily starting dose
Weeks 1-2
12.5 mg
once daily
Weeks 3-4
25 mg
once daily
Weeks 5-6
50 mg
once daily
Weeks 7-8
100 mg
once daily
Weeks 9-10
150 mg
once daily
Recommended Maintenance
Dosage
Week 11 &
thereafter
200 mg
once daily
Recommended Maintenance Dosage
Not actual sizes.
XCOPRI may be taken any time, whole or crushed, with or without food.
Maximum dosage: Dosage may be increased above 200 mg/day by increments of 50 mg/day every 2 weeks to a maximum of 400 mg/day.
Patients with mild or moderate hepatic impairment: 200 mg/day is the maximum dosage. XCOPRI is not recommended for use in patients with severe hepatic impairment.
See Prescribing Information for additional Dosage and Administration instructions.
GETTING STARTED
Prescribing: From start to maintenance1
Below is an example* of a titration schedule for prescribing XCOPRI. After you have titrated up to find the right maintenance dosage, maintenance blister packs and bottles are available.
MAINTENANCE DOSING
Flexible, once-daily dosing—from start to maintenance
XCOPRI Titration Blister Packs
Designed to simplify the titration schedule of XCOPRI. At-a-glance instructions have been included to assist you and your patients as XCOPRI dosages are increased over time.1
12.5 mg/25 mg (28-day supply)
50 mg/100 mg (28-day supply)
150 mg/200 mg (28-day supply)
XCOPRI Bottles
Maintenance bottles available:
• 25 mg (30-count bottle)
• 50 mg (30-count bottle)
• 100 mg (30-count bottle)
• 150 mg (30-count bottle)
• 200 mg (30-count bottle)
XCOPRI Maintenance Blister Packs
Designed to give you the flexibility to find the dosage that is right for your individual patients.1
Maintenance blister packs available:
• 250 mg [28-day supply]
• 350 mg [28-day supply]
MANAGING ADJUNCTIVE THERAPY
Managing the adjunctive use of XCOPRI
Managing the Adjunctive Use of XCOPRI
In this interactive video, watch as Lawrence Seiden, MD and Barry Gidal, PharmD discuss anti-seizure medication (ASM) dosing considerations to be aware of when adding XCOPRI to a patient’s treatment regimen. Discover essential information regarding the optimization of XCOPRI’s efficacy, plus potential ways to minimize side effects—and be sure to bookmark for reference.
(anti-seizure medication)
XCOPRI makes the concentration of some drugs go up. Consider decreasing the dosage of clobazam, phenytoin, and phenobarbital early in XCOPRI titration.1,2
If a patient experiences common adverse events, consider decreasing the dosage of other ASMs.1,2*
Find more information for prescribing XCOPRI with concomitant medications